I live in Plymouth and felt the need (issues at the mo...) to travel to Hull on the bike. 342miles in total and to be honest you have to stop for around 15minutes every hundred miles to relieve numb bumb syndrome o.o So filling it up every hundred (£9 ish) is not inconvenient in the slightest!
Am getting around 150miles to a tank at the moment (£10 fill up) so its not bad at all really =)